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301130

EVALUATION OF THE EFFICACY AND TOXICITY OF NEO-ADJUVANT SHORT COURSE RADIATION THERAPY CONCURRENTLY WITH CONTINUOUS INFUSION 5-FLUOROURACIL IN THE MANAGEMENT OF LOCALLY ADVANCED

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Last updated: 25 Dec 2024

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Abstract

Purpose: To assess the safety and efficacy of neo-adjuvant short-course radiation therapy (SCRT) concurrently with continuous infusion of 5-fluorouracil (5-FU) in the treatment of locally advanced rectal cancer. Method and material:Patients with cT3-4 or any T with N+ rectal cancer diagnosed by magnetic resonance imaging (MRI) and proved pathologically as adenocarcinoma were eligible to be enrolled in our study. Patients received continuous infusion of 5-FU with dose escalation from 100mg/m2/day up to 200mg/m2/day through 5 days concurrently with a SCRT (5 Gy x 5 fractions), followed by 2 months of neo-adjuvant mFOLFOX, radical surgery with total mesorectal excision (TME) was done for patients with complete clinical (cCR), partial response (PR) or stationary disease (SD) and was follow by 4 months of adjuvant mFOLFOX. Results: Twenty patients were included in the study. All patients completed a SCRT concurrently with 5-FU and the 5-FU dose was safely escalated to 200 mg/m2/d with no dose-limiting toxicity (DLT). Four patients (20%) out of 20 patients showed cCR, 14 patients (7o%) had PR, and 2 patients (10%) had disease progression (PD). Four patients (26.7) out of 15 patients had complete pathological response (pCR), and 11 patients (73.3%) had PR.  The most common grade III and Ⅳ toxicities according to common terminology criteria of adverse events version 5.0 (CTCAE) were diarrhea and abdominal pain. The most common grade Ⅰ and Ⅱ toxicities were non-hematological toxicity mainly gastrointestinal.

DOI

10.21608/bfsa.2023.301130

Keywords

5-Fluorouracil, Total Mesorectal Excision, dose-limiting toxicity, complete pathological response, common terminology criteria of adverse events version 5.0

Authors

First Name

Radwan

Last Name

Torky

MiddleName

-

Affiliation

General Surgery Department, Assuit University Hospital, Egypt

Email

radwan.surgeon@aun.edu.eg

City

-

Orcid

-

First Name

Mariam

Last Name

Khalil

MiddleName

Mohsen

Affiliation

Clinical Oncology Department, Assiut university, Assiut, Egypt

Email

mariammohsenkhalil@aun.edu.eg

City

-

Orcid

0000-0002-7351-6441

First Name

Taha

Last Name

Zaky

MiddleName

-

Affiliation

Clinical Oncology Department, Assuit University Hospital, Egypt

Email

-

City

-

Orcid

-

First Name

Mostafa

Last Name

Elsayed

MiddleName

-

Affiliation

Radiation Oncology Department, South Egypt Institute, Egypt

Email

-

City

-

Orcid

-

First Name

Abeer

Last Name

Fayek

MiddleName

-

Affiliation

General Surgery Department, Assuit University Hospital, Egypt

Email

-

City

-

Orcid

-

First Name

Maha

Last Name

Salah

MiddleName

-

Affiliation

General Surgery Department, Assuit University Hospital, Egypt

Email

-

City

-

Orcid

-

Volume

46

Article Issue

1

Related Issue

41495

Issue Date

2023-06-01

Receive Date

2023-01-10

Publish Date

2023-06-01

Page Start

389

Page End

397

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 1_Pages 389-397.pdf

PDF . 1.4MB

Link

https://bpsa.journals.ekb.eg/article_301130.html

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https://bpsa.journals.ekb.eg/service?article_code=301130

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301,130

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EVALUATION OF THE EFFICACY AND TOXICITY OF NEO-ADJUVANT SHORT COURSE RADIATION THERAPY CONCURRENTLY WITH CONTINUOUS INFUSION 5-FLUOROURACIL IN THE MANAGEMENT OF LOCALLY ADVANCED RECTAL CANCER PATIENTS

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Article

Created At

25 Dec 2024