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301124

ASSESSMENT OF PENTOXIFYLLINE EFFECTS ON LIVER STEATOSIS UTILIZING DIXON-BASED MRI TECHNIQUE; RANDOMIZED CONTROLLED STUDY

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Last updated: 04 Jan 2025

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Abstract

Background: Pentoxifylline (PTX) has been proven to reduce hepatic steatosis in animal models; however, data regarding its safety and efficacy in type-2 diabetics (T2D) with nonalcoholic fatty liver disease (NAFLD) are rare. Aim: Determine the effects of PTX in reducing liver fat content (LFC; %) in T2D patients with NAFLD in various disease states. Methods: 187 T2D subjects with NAFLD were randomized to receive either Pentoxifylline 800 mg (PTX group) or standard T2D care only (control group) for 24 weeks. The primary outcomes included changes in LFC (%) as measured by magnetic resonance imaging-derived proton density fat-fraction technique (MRI-PDFF) and the calculation of a fibrosis score (NFS). Results: PTX significantly reduced LFC (%) more than the control group (-8.18 vs. -1.87; P< 0.0001). Only the PTX group significantly reduced the NFS score (-1.16; P<0.0001). The PTX group showed significant LFC changes in liver segments II (-9.77; P< 0.0001), IVb (-9.51; P< 0.0001), and VI (-9.13; P< 0.0001); however, the control group achieved significant LFC changes in liver segments III (-2.57; P= 0.02) and VI (-2.22; P= 0.04). In subgroup analysis, PTX showed comparable efficacy in decreasing LFC in different fibrosis scores, gender, and BMI categories. However, Patients with severe steatosis grade (LFC>22.1%) (-10.55%; P=0.001) and HbA1c levels > 7.5% (-8.75%; P= 0.015) achieved significantly higher LFC reductions than other steatosis grades and HbA1c categories. Conclusion: PTX presented a similar efficacy profile in reducing LFC in different fibrosis scores, genders, and BMI categories, while patients with severe steatosis grade and HbA1c > 7.5% achieved higher LFC reductions.

DOI

10.21608/bfsa.2023.301124

Keywords

Pentoxifylline, Liver Steatosis, diabetes, MRI-PDFF

Authors

First Name

Sahar

Last Name

H.ElHini

MiddleName

-

Affiliation

Diabetes and Endocrinology unit, Internal medicine department, Faculty of Medicine, Minia University, Minia, Egypt

Email

d.saharelhini@yahoo.co.uk

City

-

Orcid

-

First Name

Asmaa

Last Name

Elsayed

MiddleName

A.

Affiliation

Clinical Pharmacy Department, Faculty of Pharmacy, Sohag University, Sohag, Egypt

Email

asmaa.abdelfattah@pharm.sohag.edu.eg

City

-

Orcid

0000-0002-2862-5382

First Name

Ahmed

Last Name

Elberry

MiddleName

A.

Affiliation

Clinical Pharmacology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt. & Department of Pharmacy Practice, Pharmacy Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia

Email

berry_ahmed@yahoo.com

City

-

Orcid

-

First Name

Nadia

Last Name

El Ameen

MiddleName

F.

Affiliation

Radiology Department-Faculty of medicine- Minia University, Minia, Egypt

Email

-

City

-

Orcid

-

First Name

Ahmed

Last Name

Saedii

MiddleName

Abdelfadil

Affiliation

Clinical Pathology Department -faculty of medicine -Minia University, Minia, Egypt

Email

-

City

-

Orcid

-

First Name

Marwa

Last Name

Ibrahim

MiddleName

-

Affiliation

Diabetes and Endocrinology unit, Internal medicine department, Faculty of Medicine, Minia University, Minia, Egypt

Email

mrwhabrahymfraj@gmail.com

City

-

Orcid

-

First Name

Nadia

Last Name

Ismail

MiddleName

-

Affiliation

Critical care and internal medicine, Internal medicine department, Faculty of Medicine, Minia University, Minia, Egypt

Email

nadiaismail062@gmail.com

City

-

Orcid

-

First Name

Haitham

Last Name

Saeed

MiddleName

-

Affiliation

Clinical Pharmacy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt

Email

haitham.sd1@gmail.com

City

-

Orcid

-

First Name

Hoda

Last Name

Rabea

MiddleName

M.

Affiliation

Clinical Pharmacy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt

Email

hoda.ahmed@pharm.bsu.edu.eg

City

-

Orcid

-

Volume

46

Article Issue

1

Related Issue

41495

Issue Date

2023-06-01

Receive Date

2022-11-29

Publish Date

2023-06-01

Page Start

361

Page End

378

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 1_Pages 361-378.pdf

PDF . 1.6MB

Link

https://bpsa.journals.ekb.eg/article_301124.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=301124

Order

301,124

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ASSESSMENT OF PENTOXIFYLLINE EFFECTS ON LIVER STEATOSIS UTILIZING DIXON-BASED MRI TECHNIQUE; RANDOMIZED CONTROLLED STUDY

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Type

Article

Created At

25 Dec 2024