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300949

CLINICOPATHOLOGICAL AND PROGNOSTIC SIGNIFICANCE OF PLATELET TO LYMPHOCYTE RATIO IN DIFFUSE LARGE B-CELL LYMPHOMA: A META-ANALYSIS

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Last updated: 25 Dec 2024

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Abstract

Background: Nowadays, there is a significant but variable correlation between the diffuse large B-cell lymphoma (DLBL) and the platelet-lymphocyte ratio (PLR). This meta-analysis will assess this association. Methods: A thorough search was done up until June 2022, and 11 research revealed 2284 patients with DLBL. They discovered a connection between DLBL and the PLR. A fixed or random-effect model was used to construct odds ratios (ORs) with 95% confidence intervals (CIs) and examine the prognostic significance of the PLR on overall survival, progression-free survival, and a variety of clinicopathological characteristics. Results: Poor 5-years overall survival (OR, 0.59; 95% CI, 0.36-0.98, p<0.001), poor 2-years progression-free survival subjects (OR, 0.42; 95% CI, 0.27-0.67, p<0.001), and poor 5-years progression-free survival (OR, 0.50; 95% CI, 0.34-0.72, p<0.001) were all significantly correlated with high the PLR. In a similar manner, a high the PLR was strongly correlated with the presence of B-symptoms (OR, 2.22; 95% CI, 1.69-2.93, p<0.001), a high lactate dehydrogenase level (OR, 2.98; 95% CI, 2.19-4.06, p<0.001), a higher tumour stage (OR, 1.84; 95% CI, 1.08-3.13, p=0.03). Nevertheless, there was no significant correlation between a high the PLR and a high Eastern Cooperative Oncology Group performance status ≥2 (OR, 1.44; 95% CI, 0.69-3.02, p=0.33), a high bone marrow infiltration (OR, 1.02; 95% CI, 0.60-1.74, p=0.94), a person's gender (OR, 1.20; 95% CI, 0.93-1.55, p=0.17); age (OR, 0.89; 95% CI, 0.69-1.15, p=0.37); and cell of origin (OR, 1.00; 95% CI, 0.71-1.39, p=0.98). Conclusions:  The impact of the PLR on DLBL may be substantial as a technique to enhance prognosis. Patients with DLBL who have a high the PLR may be at an independent risk for having a poor prognosis. To prevent potential problems, we advise keeping track of patients with a high platelet-to-lymphocyte ratio.

DOI

10.21608/bfsa.2023.300949

Keywords

Platelet to Lymphocyte ratio, Diffuse large B-cell lymphoma, Overall survival, progression-free survival, B symptoms, elevated lactate dehydrogenase, higher tumor stage, Eastern Cooperative Oncology Group performance status, international prognostic index, Infiltration of bone marrow

Authors

First Name

Haitham

Last Name

Saeed

MiddleName

-

Affiliation

Clinical Pharmacy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt

Email

haitham.sd1@gmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Shaaban

MiddleName

EA

Affiliation

Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt

Email

m0hamed.essamit2000@gmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Abdelrahim

MiddleName

E.A.

Affiliation

Clinical Pharmacy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt

Email

mohamedemam9@yahoo.com

City

-

Orcid

0000-0003-0227-8404

Volume

46

Article Issue

1

Related Issue

41495

Issue Date

2023-06-01

Receive Date

2022-11-15

Publish Date

2023-06-01

Page Start

291

Page End

304

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 1_Pages 291-304.pdf

PDF . 1.4MB

Link

https://bpsa.journals.ekb.eg/article_300949.html

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https://bpsa.journals.ekb.eg/service?article_code=300949

Order

300,949

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

CLINICOPATHOLOGICAL AND PROGNOSTIC SIGNIFICANCE OF PLATELET TO LYMPHOCYTE RATIO IN DIFFUSE LARGE B-CELL LYMPHOMA: A META-ANALYSIS

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Article

Created At

25 Dec 2024