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SECONDARY METABOLITES FROM THE STEM BARK OF POLYALTHIA STENOPETALA (HOOK. F. & THOMSON) RIDL. AND THEIR ACETYLCHOLINESTERASE ACTIVITY

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Last updated: 04 Jan 2025

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Abstract

Plants have always been a common source of medicaments, either in the form of traditional preparations or as pure active principles. Polyalthia belong to the Annonaceae family and are a type of evergreen trees distributed across many tropical and subtropical regions. Polyalthia stenopetala is locally used to treat rheumatic fever and diarrhea. Herein, we report the phytochemical composition and acetylcholinesterase (AChE) inhibitory activity of Polyalthia stenopetala. Fractionation and purification of the stem bark extract of P. stenopetala led to isolation and identification of laurotetanine (1), N-methyllaurotetanine (2), reticuline (3), liriodenine (4), yangambin (5), syringaresinol (6), vanillic acid (7), 4-hydroxybenzoic acid (8), cinnamic acid (9), and syringic acid (10). Structures of these ten compounds were elucidated using different spectral analyses and their comparison with previously reported data. All isolated compounds were found to inhibit AChE (inhibition of 40.2 to 80.6%). Our study highlights the potential of Polyalthia species as phytomedicinal sources.

DOI

10.21608/bfsa.2023.300925

Keywords

Annonaceae, Polyalthia stenopetala, alkaloid, lignan, Acetylcholinesterase

Authors

First Name

Wan Mohd Nuzul Hakimi Wan

Last Name

Salleh

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak, Malaysia

Email

wmnhakimi@fsmt.upsi.edu.my

City

Tanjung Malim

Orcid

0000-0003-1408-229X

First Name

Natasa

Last Name

Shakri

MiddleName

Mohd

Affiliation

Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak, Malaysia

Email

-

City

-

Orcid

-

First Name

Mohd

Last Name

Nafiah

MiddleName

Azlan

Affiliation

Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak, Malaysia

Email

-

City

-

Orcid

-

First Name

Nurunajah

Last Name

Ghani

MiddleName

Ab

Affiliation

Atta-ur-Rahman Institute for Natural Product Discovery (AuRIns), Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia / Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia

Email

-

City

-

Orcid

-

First Name

Salam

Last Name

Abed

MiddleName

Ahmed

Affiliation

Department of Pharmacognosy, College of Pharmacy, University of Kerbala, Iraq

Email

-

City

-

Orcid

-

First Name

Abu-Baker

Last Name

Abdel-Aal

MiddleName

M.

Affiliation

Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak, Malaysia / Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

Email

-

City

-

Orcid

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Volume

46

Article Issue

1

Related Issue

41495

Issue Date

2023-06-01

Receive Date

2022-08-26

Publish Date

2023-06-01

Page Start

217

Page End

223

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 1_Pages 217-223.pdf

PDF . 462.6kB

Link

https://bpsa.journals.ekb.eg/article_300925.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=300925

Order

300,925

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SECONDARY METABOLITES FROM THE STEM BARK OF POLYALTHIA STENOPETALA (HOOK. F. & THOMSON) RIDL. AND THEIR ACETYLCHOLINESTERASE ACTIVITY

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Type

Article

Created At

25 Dec 2024