Beta
ManageSearchChatDiscover
300770

APPLICATION OF FAST NON- INVASIVE SOLID STATE ANALYSIS ON COUNTERFEIT TRACING OF PHARMACEUTICAL DRUG EXCIPIENTS

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Near-infrared (NIR) spectroscopy has long been used for quantitative and qualitative analysis. It offers the advantages of being rapid and non-destructive technique. Pharmaceutical analysis is always concerned with active pharmaceutical ingredients (APIs), while no focus is done on the analysis of excipients used in pharmaceutical dosage forms. In this study, the NIR spectra of most commonly used excipients are presented, the interpretation of such spectra can be used as a reference in counterfeit tracing during pharmaceutical analysis. In this article, twenty two excepients are studied which fall into seven classes:  disaccharides [β-lactose anhydrous, α-lactose monohydrate and sucrose], polysaccharides [corn starch, wheat starch, sodium starch glycolate, maltodextrin, croscarmellose sodium, microcrystalline cellulose,  hydroxypropyl cellulose and hypromellose (hydroxypropylmethyl cellulose)],  a fatty acid and its salt [stearic acid and magnesium stearate], a carboxylic acid salt [potassium sorbate] inorganic compounds [calcium carbonate, dibasic calcium phosphate, silicon dioxide and talc], an anionic surfactant [sodium lauryl sulphate (sodium dodecyl sulphate)] and unclassified compounds [calcium ascorbate, candelilla wax and polyvinylpyrrolidone]. Counterfeit tracing was applied for samples representing each class of excipients by examination of their NIR spectra followed by comparison with the related spectra of the standards

DOI

10.21608/bfsa.2023.300770

Keywords

NIR spectroscopy, excipients, Pharmaceuticals

Authors

First Name

Hassan

Last Name

H. Ali

MiddleName

Refat

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Egypt

Email

-

City

-

Orcid

-

First Name

Reem

Last Name

Shahin

MiddleName

Y.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sphinx University, New Assiut 10, Egypt

Email

reem.shahin@sphinx.edu.eg

City

-

Orcid

0000-0001-6233-6560

Volume

46

Article Issue

1

Related Issue

41495

Issue Date

2023-06-01

Receive Date

2022-08-28

Publish Date

2023-06-01

Page Start

117

Page End

127

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 1_Pages 117-127.pdf

PDF . 918.2kB

Link

https://bpsa.journals.ekb.eg/article_300770.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=300770

Order

300,770

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

APPLICATION OF FAST NON- INVASIVE SOLID STATE ANALYSIS ON COUNTERFEIT TRACING OF PHARMACEUTICAL DRUG EXCIPIENTS

Details

Type

Article

Created At

25 Dec 2024