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300765

QUALITATIVE PHYTOCHEMICAL SCREENING, ANTIOXIDANT AND WOUND HEALING ACTIVITIES OF PISTACIA PALAESTINA BOISS. EXTRACTS

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Last updated: 04 Jan 2025

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Abstract

The current work was designed to undertake a qualitative phytochemical screening of various plant parts of Pistacia palaestina, and estimate antioxidant and wound healing activities for therapeutic applications. The qualitative phytochemical screening of the leaf and the fruit of P. palaestina was performed using different chemical tests. The total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activity were determined by using Folin-Ciocalteu, aluminum chloride, and DPPH (2,2-Diphenyl-1-picryl hydrazyl) methods, respectively. The extracts with the highest TPC and TFC were examined for their wound healing activity using an incision wound model on rats. The qualitative phytochemical screening revealed the presence of phenols, tannins, flavonoids, carbohydrates, saponins, phytosterols, terpenoids, mucilages, and resins, whereas no coumarins, alkaloids, cardiac glycosides, or anthraquinones were found. TPC and TFC were observed between (144.80 ± 8.81 to 489.79 ± 15.09 mg gallic acid equivalent (GAE)/g extract) and (18.34 ± 1.16 to 36.16 ± 1.05 mg rutin equivalent (RUE)/g extract), respectively. Methanolic extracts of leaves and fruits showed high antioxidant activity with IC50 about 5.16 ± 1.22 and 8.21 ± 1.87 μg/mL, respectively, which are slightly higher than ascorbic acid (IC50 = 3.52 ± 0.14 μg/mL). The prepared ointments from methanolic extracts significantly accelerated wound healing compared to a negative control group, as the final time of healing was 8.2 ± 1.30 (fruits), 9.6 ± 1.14 (leaves), 12 ± 1.22 (gentamicin ointment 0.1%) and more than 21 (negative control) days. In conclusion, P. palaestina could be used for the treatment of skin wounds

DOI

10.21608/bfsa.2023.300765

Keywords

Pistacia palaestina, Antioxidant activity, Qualitative phytochemical screening, Wound healing, TPC

Authors

First Name

Mohammed

Last Name

Alshlash

MiddleName

-

Affiliation

Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria

Email

mohammedalshlash994@gmail.com

City

-

Orcid

0000-0001-5548-9382

First Name

Adawia

Last Name

Kitaz

MiddleName

-

Affiliation

Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria

Email

d.adawiakitaz@hotmail.com

City

-

Orcid

-

First Name

Wassim

Last Name

Abdelwahed

MiddleName

-

Affiliation

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria

Email

wassimabed@yahoo.fr

City

-

Orcid

-

Volume

46

Article Issue

1

Related Issue

41495

Issue Date

2023-06-01

Receive Date

2022-10-25

Publish Date

2023-06-01

Page Start

83

Page End

96

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 1_Pages 83-96.pdf

PDF . 1.3MB

Link

https://bpsa.journals.ekb.eg/article_300765.html

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https://bpsa.journals.ekb.eg/service?article_code=300765

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300,765

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

QUALITATIVE PHYTOCHEMICAL SCREENING, ANTIOXIDANT AND WOUND HEALING ACTIVITIES OF PISTACIA PALAESTINA BOISS. EXTRACTS

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Type

Article

Created At

25 Dec 2024