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300757

CYTOTOXIC AND ANTIMICROBIAL EFFECTS OF SELECTED EGYPTIAN ASTERACEAE SPECIES AS WELL AS GC-MS METABOLITE PROFILING OF SENECIO CRUENTUS LIPOPHILIC FRACTION

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Last updated: 25 Dec 2024

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Abstract

The ethanol extracts of three ornamental Asteraceae species; Senecio cruentus DC., Dimorphotheca ecklonis DC. and Arctotis aurantiaca L. were studied for their cytotoxicity against Panc1 and antimicrobial activities against selected microbial strains. Lipophilic fraction of S. cruentus showed the most active cytotoxic extract (IC50 = 7.63±0.46 µg/ml) and was subjected to metabolite profiling by using GC-MS. Seventeen compounds of different categories were identified. The detection of phytol as well as unsaturated fatty acids/esters; cis-vaccenic acid (C18:1), glycidyl oleate (C21:1), 9,12-Octadecadienoic acid (Z,Z)- methyl ester (C19:2), 9,12,15-(Z,Z,Z)- Octadecatrienoic acid, 2,3-dihydroxypropyl ester, (C21:3) and Z,Z-3,15-Octadecadien-1-ol acetate (C20:2) are suggesting its cytotoxicity. The S. cruentus lipophilic fraction exhibited potent cytotoxic activity against A549 (lung) cancer cells (IC50 = 1.919±0.1 µg/ml) through inhibition of cell growth at G1/S stage. All the species displayed moderate antimicrobial activities against certain types of selected strains. The LD50 of S. cruentus ethanol extract was determined as 1.5 g/kg.

DOI

10.21608/bfsa.2023.300757

Keywords

Asteraceae, Senecio cruentus, Panc1 cells, A549 cells, GC-MS

Authors

First Name

Youstina

Last Name

A. Malak

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Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, 71515 Assiut, Egypt / Department of Pharmacognosy, Faculty of Pharmacy, South Valley University, Qena, Egypt

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Orcid

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First Name

Khaled

Last Name

M. Mohamed

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-

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Fayoum University, 63514 Fayoum, Egypt

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Orcid

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First Name

Ahmed

Last Name

M. A. Abd El-Mawla

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Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, 71515 Assiut, Egypt

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City

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Orcid

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First Name

Ahmed

Last Name

M. Zaher

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-

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, 71515 Assiut, Egypt

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Volume

46

Article Issue

1

Related Issue

41495

Issue Date

2023-06-01

Receive Date

2022-08-13

Publish Date

2023-06-01

Page Start

39

Page End

49

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 1_Pages 39-49.pdf

PDF . 912.1kB

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https://bpsa.journals.ekb.eg/article_300757.html

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https://bpsa.journals.ekb.eg/service?article_code=300757

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300,757

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

CYTOTOXIC AND ANTIMICROBIAL EFFECTS OF SELECTED EGYPTIAN ASTERACEAE SPECIES AS WELL AS GC-MS METABOLITE PROFILING OF SENECIO CRUENTUS LIPOPHILIC FRACTION

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Article

Created At

25 Dec 2024