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COMPLICATIONS ASSOCIATED WOUND HEALING IN DIABETIC PATIENTS: DOES NANOTECHNOLOGY HAVE ANY SUPERIOR THERAPEUTIC ADVANTAGES?

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Last updated: 04 Jan 2025

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Abstract

Delayed wound healing is one of the main complications facing diabetic patients worldwide. It can be followed by serious consequences such as ulcer, gangrene, amputation unless treated correctly. Four phases of normal wound healing are compromised in diabetic patients due to complex pathophysiology; thus, wounds healing time is prolonged. Consequently, the probability of wounds infections in diabetic patients is higher than non-diabetic patient and it is much higher with immunocompromised diabetic patients. There are several strategies for treatment of diabetic wounds such as; dressings, growth factors, stem cells, antidiabetic drugs, antihypertensive drug, etc. However, some of these strategies are still under investigations to ascertain their safety, while others are clinically non-applicable due to rapid biodegradation. Nanotechnology might be a novel and a promising alternative strategy for diabetic wound healing as nanoparticles could overcome limitations of medical products currently used. Some nanoparticles such as; metal-based nanoparticles (MBNPs) demonstrated an excellent antibacterial activity including resistant strains inhabitant diabetic wound, moreover, some of MBNPs could enhance the healing of wound in diabetic patients via modulating many disturbed issues recorded in four phases of wound healing. This review explores the recent literature in this area, discusses the complications associated diabetic patients with special focus on delayed wound healing, pathophysiology of wound healing in diabetic patients, treatment approved for wound healing and controlling wound infection. In addition, shedding the light on nanotechnology application to improve wound healing, with a special concern devoted to MBNPs including their antibacterial mechanisms and barriers faced to their clinical application.

DOI

10.21608/bfsa.2023.300755

Keywords

diabetes, Metal-based Nanoparticles, Wound healing

Authors

First Name

Gehad

Last Name

E. Elkhouly

MiddleName

-

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, Cairo 11795, Egypt , Helwan Nanotechnology Center, Helwan University, Cairo 11792, Egypt

Email

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City

-

Orcid

-

First Name

Aliaa

Last Name

Ismail

MiddleName

-

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, Cairo 11795, Egypt

Email

aliaa_adly@pharm.helwan.edu.eg

City

-

Orcid

-

First Name

Yasmin

Last Name

Abo-zeid

MiddleName

-

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, Cairo 11795, Egypt, Helwan Nanotechnology Center, Helwan University, Cairo 11792, Egypt

Email

yasmin.abozeid@pharm.helwan.edu.eg

City

-

Orcid

0000-0002-1651-7421

Volume

46

Article Issue

1

Related Issue

41495

Issue Date

2023-06-01

Receive Date

2022-09-16

Publish Date

2023-06-01

Page Start

13

Page End

38

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 1_Pages 13-38.pdf

PDF . 1.3MB

Link

https://bpsa.journals.ekb.eg/article_300755.html

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https://bpsa.journals.ekb.eg/service?article_code=300755

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300,755

Type

Review Article

Type Code

2,839

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

COMPLICATIONS ASSOCIATED WOUND HEALING IN DIABETIC PATIENTS: DOES NANOTECHNOLOGY HAVE ANY SUPERIOR THERAPEUTIC ADVANTAGES?

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Article

Created At

25 Dec 2024