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300752

DESIGN AND EVALUATION OF ANTIUROLITHIATIC EFFERVESCENT HERBAL TABLETS CONTAINING HYDROALCOHOLIC EXTRACT OF BRYOPHYLLUM PINNATUM

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Last updated: 25 Dec 2024

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Abstract

The objective of this study was to prepare and evaluate effervescent tablets containing Bryophyllum pinnatum leaves extract and to assess the in vitro antiurolithiatic activity of these tablets. The leaves of Bryophyllum pinnatum were collected, authenticated, cleaned, dried and extracted using water:ethanol (80:20) as the solvent system. Prior to extraction the crude drug was tested for its macroscopic, microscopic and quantitative standards. The extract was also assessed for its antioxidant potential by determining the DPPH radical, hydroxyl radical, nitric oxide radical and hydrogen peroxide radical scavenging activities; total phenolic and total flavonoid contents. Thereafter, the extract was formulated into an effervescent tablet and characterized for its different evaluation parameters as described previously. The formulated tablets were then assessed for its in vitro antiurolithiatic activity through estimation of the rate of nucleation and aggregation of CaOx crystals. The results were compared with a standard marketed formulation, Cystone®. Statistical analyses were performed using GraphPad Prism software (v6.01, Sept 2012). The antioxidant studies indicated that the Bryophyllum pinnatum extract has high antioxidant potential. The effervescent tablets were prepared by wet granulation method and passed all the evaluation tests, viz. weight variation test, effervescence time, effervescence solution pH, hardness test, thickness of tablets, moisture content and friability. The tablets also demonstrated superior antiurolithiatic activity by reducing the rate of nucleation and aggregation of CaOx crystals.

DOI

10.21608/bfsa.2023.300752

Keywords

calcium oxalate, Bryophyllum pinnatum, Effervescent tablets, nucleation, Aggregation

Authors

First Name

Banshongdor

Last Name

Mawlieh

MiddleName

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Affiliation

NETES Institute of Pharmaceutical Science, Shantipur, Mirza, Kamrup, Assam, India, PIN – 781125

Email

ban.mawlieh@yahoo.com

City

-

Orcid

-

First Name

Kangkan

Last Name

Kalita

MiddleName

-

Affiliation

NETES Institute of Pharmaceutical Science, Shantipur, Mirza, Kamrup, Assam, India, PIN – 781125

Email

kankankalita108@gmail.com

City

-

Orcid

-

First Name

Bhargab

Last Name

Jyoti Sahariah

MiddleName

-

Affiliation

NETES Institute of Pharmaceutical Science, Shantipur, Mirza, Kamrup, Assam, India, PIN – 781125

Email

-

City

-

Orcid

-

First Name

Apurba

Last Name

Talukdar

MiddleName

-

Affiliation

NETES Institute of Pharmaceutical Science, Shantipur, Mirza, Kamrup, Assam, India, PIN – 781125

Email

apurbatalukdar83@gmail.com

City

-

Orcid

0000-0001-9538-2512

First Name

Nilutpal

Last Name

Sharma Bora

MiddleName

-

Affiliation

NETES Institute of Pharmaceutical Science, Shantipur, Mirza, Kamrup, Assam, India, PIN – 781125

Email

-

City

-

Orcid

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Volume

46

Article Issue

1

Related Issue

41495

Issue Date

2023-06-01

Receive Date

2022-08-19

Publish Date

2023-06-01

Page Start

1

Page End

11

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 1_Pages 1-11.pdf

PDF . 1.4MB

Link

https://bpsa.journals.ekb.eg/article_300752.html

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https://bpsa.journals.ekb.eg/service?article_code=300752

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300,752

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

DESIGN AND EVALUATION OF ANTIUROLITHIATIC EFFERVESCENT HERBAL TABLETS CONTAINING HYDROALCOHOLIC EXTRACT OF BRYOPHYLLUM PINNATUM

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Article

Created At

25 Dec 2024