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345095

SYNTHESIS OF CERTAIN PYRAZOLO[3,4-d] PYRIMIDINE DERIVATIVES OF POTENTIAL ANTI-INFLAMMATORY ACTIVITY

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Last updated: 25 Dec 2024

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Abstract

The synthesis of twenty nine novel derivatives of pyrazolo[3,4-d]pyrimidines as non acidic nonsteroidal anti-inflammatory drugs has been achieved via reaction of 4-chloro-1-phenylpyrazolo[3,4-d]pyrimidine with different substituents including 4-amino-3-methylphenol, 4-phenylene diamine and 4-acetamidophenol.The anti-inflammatory activity of thirteen representative compounds have been screened compared to indomethacin as a reference drug. The results revealed that all the tested compounds showed anti-inflammatory activity with the exception of 10a.
 

DOI

10.21608/bfsa.2008.345095

Authors

First Name

Safinaz

Last Name

Abbas

MiddleName

E. S.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Egypt

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Orcid

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First Name

Hanan

Last Name

Georgey

MiddleName

H.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Egypt

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Orcid

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First Name

Shimaa

Last Name

Abdelrahman

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Egypt

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Orcid

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First Name

Gamil

Last Name

El-Taliawi

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Egypt

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Volume

31

Article Issue

2

Related Issue

9716

Issue Date

2008-12-01

Receive Date

2008-06-26

Publish Date

2008-12-01

Page Start

197

Page End

214

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 31_Issue 2_Pages 197-214.pdf

PDF . 567.8kB

Link

https://bpsa.journals.ekb.eg/article_345095.html

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https://bpsa.journals.ekb.eg/service?article_code=345095

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Original Article

Type Code

1,096

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Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SYNTHESIS OF CERTAIN PYRAZOLO[3,4-d] PYRIMIDINE DERIVATIVES OF POTENTIAL ANTI-INFLAMMATORY ACTIVITY

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Article

Created At

25 Dec 2024