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327565

The Impacts of Teriparatide Treatment on Bone Alkaline Phosphatase, Calcium and Phosphate Serum Levels in Rats

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Surgery

Abstract

Trauma, tooth loss, cancer surgery, congenital malformations, periodontal disease, and oral-maxillofacial surgery are all major causes of bone loss, deformity, or fracture. Bone healing is a physiologically complicated process that also incorporates mechanical factors. Too many doubts concerning bone regeneration and the conditions that promote it have persisted for far too long. To assess the impact of systemic teriparatide therapy on mandibular bone defects healing.Forty male albino rats were randomly divided into two groups: the control group and the treatment group, with 20 rats per group. All rats had the same surgical technique. A small hole was created in the mandible, measuring 3 mm in diameter and 3 mm in depth, and then left unoccupied. The treatment group received a daily subcutaneous injection of Teriparatide at a dose of 10 µg/kg. Animals were subjected to euthanasia at four distinct time intervals (7, 14, 21, and 28) days. Biochemical analyses were done. Teriparatide was shown to elevate serum levels of bone alkaline phosphatase (BALP), elevate serum calcium concentration levels, and lower serum phosphate. There were statistically significant differences in the levels of BALP between the control group and the treated group at 7, 14, and 21 days after the surgical procedure and there was a statistically significant difference in serum calcium levels between the treated group and the control group on day 14 of the experiment. The findings of this research suggest that the systemic administration of teriparatide resulted in an acceleration of bone healing. This was evidenced by a notable elevation in bone alkaline phosphatase levels as seen in the biochemical analysis. Teriparatide slightly elevated serum calcium levels and lowered serum phosphate levels because it is a synthetic parathyroid hormone.

DOI

10.21608/javs.2023.240748.1281

Keywords

Bone alkaline phosphatase, bone healing, rat, teriparatide

Authors

First Name

Duaa

Last Name

Ahmed

MiddleName

-

Affiliation

Ministry of Health, Nineveh Health Directorate, Mosul, Iraq

Email

duaa.21dep52@student.uomosul.edu.iq

City

Mosul

Orcid

-

First Name

Wael

Last Name

Al-Wattar

MiddleName

-

Affiliation

Department of Oral and Maxillofacial Surgery, College of Dentistry, University of Mosul , Mosul, Iraq

Email

wael_1969@uomosul.edu.iq

City

-

Orcid

-

First Name

Ghada A.

Last Name

Taqa

MiddleName

-

Affiliation

Professor in veterinary pharmacology and toxicology, College of Dentistry , Mosul university , Iraq

Email

ghada.abd.taqa@gmail.com

City

-

Orcid

-

Volume

9

Article Issue

1

Related Issue

44890

Issue Date

2024-01-01

Receive Date

2023-10-04

Publish Date

2024-01-01

Page Start

55

Page End

60

Print ISSN

1687-4072

Online ISSN

2090-3308

Article File

JAVS_Volume 9_Issue 1_Pages 55-60.pdf

PDF . 508.7kB

Link

https://javs.journals.ekb.eg/article_327565.html

Detail API

https://javs.journals.ekb.eg/service?article_code=327565

Order

6

Type

Original Article

Type Code

1,095

Publication Type

Journal

Publication Title

Journal of Applied Veterinary Sciences

Publication Link

https://javs.journals.ekb.eg/

MainTitle

The Impacts of Teriparatide Treatment on Bone Alkaline Phosphatase, Calcium and Phosphate Serum Levels in Rats

Details

Type

Article

Created At

25 Dec 2024