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314661

Screening of Some Changes in Hematological, Serum Biochemical, Inflammatory and Oxidative Parameters Associated with Pathogenesis of Retained Placenta in Holstein Dairy Heifers

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Pathology and clinical pathology

Abstract

Retained placenta is still one of the major problems facing dairy farms, and up until now, haematological and biochemical changes related to the condition of retained placenta have been mysterious. Our study aimed to screen the presumptive serum biochemical and haematological alterations in relation to the pathogenesis of retained placenta in dairy Holstein heifers. Twenty heifers were used in this study; ten of them suffered from retained placenta, and the others were kept under control as they expelled their placenta within the reference time range after parturition. Concerning serum biochemical changes, heifers affected by retained placenta suffered from disturbances in the redox state and exhaustion of enzymatic and non-enzymatic antioxidants. In addition, the serum concentration of anti-inflammatory interleukin-13 was increased in association with an elevated level of serum mucin-1, C-reactive protein and alpha-1 anti-trypsin in these heifers. Also, retained placenta induced a decrement in the serum levels of inteleukin-8 (IL-8), prostaglandin F-2 alpha (PGF-2α) and an increment in the serum level of prostaglandin-E2 (PGE-2). Moreover, serum concentrations of non-esterified fatty acids (NEFA) and creatine kinase enzyme activity were elevated in heifers with retained placentas. Haematological results did not show any significant change in RBCs count, haemoglobin concentration, hematocrit%, or platelet count between the two groups. Controversially, the total leukocytic count, granulocytes, lymphocytes and monocytes counts were elevated in cows with retained placentas. In conclusion, the retained placenta condition is accompanied by oxidative stress and inflammatory disturbances that directly affect the metabolic and hormonal states of dairy heifers.

DOI

10.21608/javs.2023.216750.1243

Keywords

hematology, Holstein dairy heifers, Interleukins, Oxidative Stress, Prostaglandins, retained placenta

Authors

First Name

Dina

Last Name

El-Karim

MiddleName

-

Affiliation

Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Alexandria University, Egypt

Email

dina.shabaan@alexu.edu.eg

City

Alexandria

Orcid

-

First Name

Gamal

Last Name

El-Amrawi

MiddleName

-

Affiliation

Department of Theriogenology, Faculty of Veterinary Medicine, Alexandria University, Egypt

Email

gamrawi@alexu.edu.eg

City

Alexandria

Orcid

0000-0001-6391-5935

Volume

8

Article Issue

4

Related Issue

42650

Issue Date

2023-10-01

Receive Date

2023-06-10

Publish Date

2023-10-03

Page Start

13

Page End

19

Print ISSN

1687-4072

Online ISSN

2090-3308

Article File

JAVS_Volume 8_Issue 4_Pages 13-19.pdf

PDF . 500.9kB

Link

https://javs.journals.ekb.eg/article_314661.html

Detail API

https://javs.journals.ekb.eg/service?article_code=314661

Order

3

Type

Original Article

Type Code

1,095

Publication Type

Journal

Publication Title

Journal of Applied Veterinary Sciences

Publication Link

https://javs.journals.ekb.eg/

MainTitle

Screening of Some Changes in Hematological, Serum Biochemical, Inflammatory and Oxidative Parameters Associated with Pathogenesis of Retained Placenta in Holstein Dairy Heifers

Details

Type

Article

Created At

25 Dec 2024