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309964

Potential Deleterious Effects Following the First Dose of Medroxyprogesterone Acetate as a Contraceptive in Cats

Article

Last updated: 04 Jan 2025

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Subjects

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Tags

Surgery

Abstract

The aim of the present work was to investigate the deleterious effects of the first dose of medroxyprogesterone acetate (MPA) on the female genital system of cats. The study was conducted on 315 cats of different breeds who received their first dose (75 mg) of MPA as a contraceptive. Complete animal identification and stage of estrus were documented at admission. Physical, radiographic and ultrasonographic examinations were done on cats that expressed deleterious manifestations. All of the presented cats received an overdose of MPA during the estrous phase of the estrous cycle. Out of 315 cats who received their first dose of MPA, 27 (8.6 %) demonstrated varied deleterious effects related to the female genital system. Deleterious effects were reported within 15–90 days, including pyometra (n=10, 37.0%), endometritis (n=8, 29.6%), mammary gland hyperplasia (n=4, 14.8 %), cystic endometrial hyperplasia (n=3, 11.2%) and ovarian cyst (n=2, 7.4%). The incidence of these adverse effects increased with age. Persian cats seem to be more susceptible than other cat breeds. Long haired cat breeds seem to be more susceptible to adverse effects following injection of exogenous progestins (MPA) than short haired breeds (Siamese and Egyptian mau). Deleterious effects of MPA occurred following the first overdose. It is advised to use MPA as a contraceptive in the recommended dose during the inter-estrous or anestrous phase.

DOI

10.21608/javs.2023.207698.1223

Keywords

CAT, contraceptive, Mammary gland, medroxyprogesterone acetate, Uterus

Authors

First Name

Ahmed

Last Name

Abdelgalil

MiddleName

I.

Affiliation

Department of Surgery, Anesthesiology and Radiology- Faculty of Veterinary Medicine - Cairo University, Giza, Egypt

Email

ismael7591@cu.edu.eg

City

-

Orcid

-

Volume

8

Article Issue

4

Related Issue

42650

Issue Date

2023-10-01

Receive Date

2023-04-28

Publish Date

2023-10-01

Page Start

1

Page End

5

Print ISSN

1687-4072

Online ISSN

2090-3308

Article File

JAVS_Volume 8_Issue 4_Pages 1-5.pdf

PDF . 599.7kB

Link

https://javs.journals.ekb.eg/article_309964.html

Detail API

https://javs.journals.ekb.eg/service?article_code=309964

Order

1

Type

Original Article

Type Code

1,095

Publication Type

Journal

Publication Title

Journal of Applied Veterinary Sciences

Publication Link

https://javs.journals.ekb.eg/

MainTitle

Potential Deleterious Effects Following the First Dose of Medroxyprogesterone Acetate as a Contraceptive in Cats

Details

Type

Article

Created At

25 Dec 2024