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306483

Acute Toxic Effects of levamisole and Ivermectin in Mice

Article

Last updated: 25 Dec 2024

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Subjects

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Tags

Pharmacology and toxicology

Abstract

The study's objectives were to investigate the acute toxicity and related biochemical effects of levamisole and ivermectin in mice. The 24 h oral median lethal dose (LD50) of levamisole was determined by the up-and-down method and was 155.5 mg/ kg of body weight. The treated mice showed signs of acute poisoning represented by excessive grooming, lacrimation, piloerection, straub tail, tachycardia, bulged eyes, tremor, convulsion and finally death within 24 h of treatment. The approximate lethal dose (ALD) of levamisole was 368 mg/kg, and the mice showed signs of poisoning similar to the previous signs of poisoning within 24 h of treatment. The 24 h oral LD50 of ivermectin was 115.2 mg/kg and the mice showed acute signs of poisoning, represented by excessive grooming, lacrimation, closed eyelids, piloerection, tachycardia, rapid respiration, depression, flat body appearance, paralysis and finally death within 24 h of treatment, while the approximate lethal dose of ivermectin was 121 mg/kg and also with the presence of severe poisoning signs as mentioned before. Non-lethal toxic doses of levamisole at 100 and 150 mg/kg and ivermectin at 75 and 100 mg/kg led to significant blood biochemical changes after 24 h of treatment, represented by a significant increase in the activity of the enzymes alkaline phosphatase (ALP), lactate dehydrogenase (LDH), glutamate dehydrogenase (GDH), and a significantly increased total bilirubin concentration in the blood plasma of mice. These results proved the presence of acute toxicity and biochemical effects of both anthelmintics levamisole and ivermectin even though they have wide safety margins.

DOI

10.21608/javs.2023.213855.1236

Keywords

Biochemical changes, Ivermectin, Levamisole, Mice, Toxic effects

Authors

First Name

Farah

Last Name

Almawla

MiddleName

F.

Affiliation

Department of Physiology, Biochemistry, and Pharmacology at the College of Veterinary Medicine, University of Mosul, Iraq

Email

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City

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Orcid

-

First Name

Banan

Last Name

Al-baggou

MiddleName

Kh.

Affiliation

Veterinary Toxicology and pharmacology, college of Veterinary Medicine ,University of Mosul,Iraq

Email

banan1971@uomosul.edu.iq

City

-

Orcid

-

Volume

8

Article Issue

3

Related Issue

42172

Issue Date

2023-07-01

Receive Date

2023-05-28

Publish Date

2023-07-01

Page Start

75

Page End

81

Print ISSN

1687-4072

Online ISSN

2090-3308

Article File

JAVS_Volume 8_Issue 3_Pages 75-81.pdf

PDF . 529.2kB

Link

https://javs.journals.ekb.eg/article_306483.html

Detail API

https://javs.journals.ekb.eg/service?article_code=306483

Order

10

Type

Original Article

Type Code

1,095

Publication Type

Journal

Publication Title

Journal of Applied Veterinary Sciences

Publication Link

https://javs.journals.ekb.eg/

MainTitle

Acute Toxic Effects of levamisole and Ivermectin in Mice

Details

Type

Article

Created At

25 Dec 2024