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Sub-acute Effects of α-Fe2O3 Nanoparticles on Some Biochemical Parameters in Mice

Article

Last updated: 25 Dec 2024

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Subjects

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Tags

Pharmacology and toxicology

Abstract

The goal  of the study was to find out the toxic effect of daily treatment with α-Fe2O3 nanoparticles for 14 and 28 days on some biochemical indicators in mice by measuring ferritin, transferrin, cholinesterase enzyme activity, the concentration of Caspase-3, and the concentration of glutathione and malondehyde in brain and liver tissues at doses of 75, 150 and 300 mg/kg. α-Fe2O3 nanoparticles at the dose of 75 mg/kg caused a significant decrease in the activity of the acetyl cholinesterase enzyme in the brain and liver after 14 days of treatment, compared with the control group and the doses of α- Fe2O3 (75, 150, and 300 mg/kg) led to a significant decrease in the activity of the acetyl cholinesterase enzyme in the brain after 28 days of treatment. Fe2O3 at a dose of 75 mg/kg on the 14th day and at a dose of 150 mg/kg on the 28th day of treatment resulted in a significant increase in the caspase-3 enzyme in the brain compared to the control group. While the doses of 150 and 300 mg/kg for 28 days led to a significant increase in transferrin concentration compared with the control group, The α-Fe2O3 nanoparticles at doses of 75, 150, and 300 mg/kg for 28 days caused a significant decrease in the concentration of glutathione in the liver and brain tissues compared with the control group, accompanied by a significant increase in the concentration of malondehyde in the brain and liver tissues at doses of 150 and 300 mg/kg of body weight. We conclude that repeated exposure to α - Fe2O3 nanoparticles has toxic effects on vital organs such as the brain and liver, represented by a decrease in the concentration of acetylcholinesterase and its ability to induce oxidative stress through a decrease in glutathione concentration and an increase in malondehyde concentration in mice .

DOI

10.21608/javs.2023.210749.1232

Keywords

Acetyl Cholinesterase, α-Fe2O3 Ferritin, Nanoparticles, Oxidative Stress, transferrin

Authors

First Name

Nashwan

Last Name

Al-hamadany

MiddleName

Adnan

Affiliation

Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq

Email

-

City

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Orcid

-

First Name

Muna

Last Name

Azubaidy

MiddleName

Hazim

Affiliation

Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq

Email

munahazim@uomosul.edu.iq

City

-

Orcid

-

Volume

8

Article Issue

3

Related Issue

42172

Issue Date

2023-07-01

Receive Date

2023-05-13

Publish Date

2023-07-01

Page Start

46

Page End

53

Print ISSN

1687-4072

Online ISSN

2090-3308

Article File

JAVS_Volume 8_Issue 3_Pages 46-53.pdf

PDF . 986.3kB

Link

https://javs.journals.ekb.eg/article_304730.html

Detail API

https://javs.journals.ekb.eg/service?article_code=304730

Order

7

Type

Original Article

Type Code

1,095

Publication Type

Journal

Publication Title

Journal of Applied Veterinary Sciences

Publication Link

https://javs.journals.ekb.eg/

MainTitle

Sub-acute Effects of α-Fe2O3 Nanoparticles on Some Biochemical Parameters in Mice

Details

Type

Article

Created At

25 Dec 2024