To ascertain the effects of Elaeis guineensis oil on the haematological and water quality parameters of Clarias gariepinus to road transportation, experiments were conducted.  Forty-two clinically healthy adult Clarias gariepinus, weighing an average of 450.46 ± 26.06 g and measuring an average total length of 38.23 ± 4.46 cm were utilized for the experiment and split into two groups. Elaeis guineensis oil was given to group I every day for one month and on the day of transportation, but not to group II. After transportation, the group I's packed cell volume and erythrocyte counts were significantly elevated (P < 0.05). In comparison to group II, the group I's total leucocyte count, neutrophil count, and stress index (neutrophil/lymphocyte ratio) were all considerably lower (P < 0.05). Following transportation, group II had significantly higher levels (P < 0.05) of nitrite, nitrate, and ammonia than group I. However, the dissolved oxygen level was significantly elevated in group I than in group II. As a result, it was determined that palm oil improved the various Clarias gariepinus haematological and water quality indicators. As a result, it can be beneficial to the fish to reduce the stress of transportation consequently mitigating the effect of stress leading to disease susceptibility and mortality of the fish.