Pharmaceutical companies are at the heart of the mobile revolution, and surely this technology will modify ways to deliver, consume, measure, and pay for healthcare. Recently, the healthcare ecosystem has radically changed to be more sophisticated due to many crises and challenges in the current global business milieu (e.g., COVID-19 and Russian-Ukrainian War). Therefore, the necessity to select smart tools that improve physician engagement at minimal cost is highly urgent. Several types of research acknowledge the impact of mobile applications on physicians' engagement. Although the Egyptian pharmaceutical industry is huge and highly competitive, unfortunately, no research investigated the characteristics of mobile application to enhance the physicians' engagement with Egyptian's pharmaceutical firms. Therefore, this research explored the characteristics, benefits, barriers, and medical information required for the mobile application. Then, the researcher suggested a mobile application prototype to advance this engagement. A quantitative survey using a questionnaire and descriptive analysis is applied in this empirical research. The research provided excellent evidence and a guideline to encourage Egyptian pharmaceutical companies to develop intelligent applications to enhance physician engagement.