Background: Healthcare students (HCSs) are prospective clinical caregivers who should be informed about COVID- 19 immunization. Aim of the work: assess the mindset of medical students towards different approved COVID- 19 vaccines and predicting the efforts of Ministry of Health & universities in detection of efficacy of vaccines. Methods: cross-sectional study included 197 HCSs at Suez University, online questionnaire distributed to them. Results: COVID- 19 cases decreased from 31.5% to 13.7% after vaccination. Also, the severity of COVID- 19 reduced significantly in vaccinated students to half. Medical students had misconception that chronic diseases prevent COVID -19 vaccines. Surveillance of COVID- 19 cases and immunization adverse effects were the most predicted factor in detection of COVID -19 cases by MOH and universities. Conclusions: Covid 19 vaccines decrease both cases and its severity. Intervention awareness programs about efficacy of vaccines should designed targeting medical students as they have an active impact on their families and the overall community.