Introduction: Cardiovascular disease (CVD) is a major health problem. Comprehending the link between CVD risk and sleep quality is crucial to promote cardiovascular health. Purpose: to assess the association between cardiovascular risk and poor sleep quality. Methods: This is a case-control study; cardiovascular risk was calculated using the Systematic Coronary Risk Evaluation (SCORE) risk scale. Fifty participants identified as high cardiovascular risk (≥5%) were considered cases, while 63 participants identified as low (≤ 2%) or intermediate cardiovascular risk (3-5%) were considered controls. Sleep quality was assessed using the Arabic version of the Pittsburgh Sleep Quality Index (PSQI), and quality of life (QOL) was assessed by the World Health Organization Quality of Life questionnaire. We evaluated the association between sleep quality, quality of life, and cardiovascular disease risk. Results: A total of 113 patients participated in this study. Comparing the case and control groups revealed a significantly poor sleep quality (P< 0.001) and a positive correlation (0.763) in the cases compared to the controls. Also, there was statistical significance between cases and controls (P<0.001) regarding all domains of quality of life. There was a significant negative correlation between PSQI score and all 4 domains of quality of life (-0.728, -0.745, -0.763, -0.715). Multivariate logistic regression revealed that poor sleep quality was significantly associated with increased CVD risk after age and sex adjustment (odds ratio 167.147). Conclusions: High cardiovascular disease risk is associated with poor sleep quality and poor quality of life, independent of age or sex.