Background: In the first six months of life, Breastfeeding has been identified as the most complete form of nutrition. There are many factors that can affect the exclusive breastfeeding practice. This study was applied to spot light on determinants of psychological effect of breast feeding as perceived stress, social support and breastfeeding self-efficacy among first-time mothers. Methods: A cross-sectional study conducted among 176 first time breastfeeding mothers using a predesigned structured questionnaire. Results: The included mothers were stratified into three groups according to their breastfeeding practices. About half of mothers 52.3% had Partial breastfeeding at 6 months, and 47.7% had exclusive breastfeeding at 6 months and no women discontinued breastfeeding before 6 months. There was a statistically significant of mother employment, (P<0.001), socioeconomic state (P<0.001), and mode of delivery (P=0.029) on breast feeding practice. There is non-statistically significant effect of perceived stress scale, social support scale and breast self-efficacy scale on breastfeeding practice Conclusion: Exclusive breastfeeding was present in 47.7% of the studied group. There was a significant relation between breastfeeding and socioeconomic status and mode of delivery, also maternal employment acts as barrier to exclusive breastfeeding