Osteoporosis is a disease that affects many millions of people around the world. The present study aimed to treated female rats' osteoporosis using sesame, sesame oil and yogurt as sources rich in calcium. The experiment was carried out at the Post Graduated Lab of Home Economics Faculty, Helwan University. Animals were housed in well aerated cages under hygienic condition and feed on basal diet for one week for adaptation. After the adaptation period, rats were be divided into two main groups, as follows: -First group: Negative control group, rats (n=7) were fed on basal diet only during the  experimental period. Second group: Rats (n=49), were received oral predisone acetate (4.5 ml/kg b.w./ day twice a week to establish osteoporotic, then the animals were divided as follow: subgroup (1): Rats (served as positive control group) were fed on basal diet only. subgroup (2): Rats were fed on basal diet supplemented with the 50g sesame per kg of basal diet. subgroup (3): Rats were fed on basal diet supplemented with the 100g sesame per kg of basal diet. subgroup (4): Rats were fed on basal diet supplemented with the 50g sesame oil per kg of basal diet. subgroup (5): Rats were fed on basal diet supplemented with the 100g sesame oil per kg of basal diet. subgroup (6): Rats were fed on basal diet supplemented with the 50g yogurt per kg of basal diet. subgroup (7): Rats were fed on basal diet supplemented with the 100g yogurt per kg of basal diet. Calcium and phosphors in serum and femur bone of rats were determined as well as liver function, BMD and BMC as well as histopathological examination were determined. According to the obtained results, it could be recommended that Sesame, sesame oil and yogurt may promote health 9 osteoporosis and liver function) so they must be taken daily. Sesame, sesame oil and yogurt daily consumption may be recommended for osteoporosis, liver function due to its beneficial effects. Nutrition education programs should be carried out to the public with the benefits of sesame, sesame oil and yogurt.