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376255

The protective Effect of Ocimum basilicum and Melissa officinalis Aqueous Extract on Aluminum -Induced Brain Toxicity in Rats

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Last updated: 25 Dec 2024

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Abstract

A lot of products that are made commercially contain aluminum chloride (AlCl3). Excessive exposure of brain cells to aluminum leads to toxicity by aluminum which enables it to pass through the blood-brain barrier, accumulate in the brain and (Al) may also change brain neurotransmitters and impede the function of antioxidant enzymes which lead to worsen neurological dysfunction and cause brain toxicity. This study aimed to protect and enhance brain cells from harmful effects of (Al3Cl) via utilization herbs are known to have contents of strong antioxidants that scavenge free radicals. Sweet basil and lemon balm contained mimic phenolic compounds and flavonoids such as rosmarinic acid and luteolin. Rats were divided into seven groups: negative control group(normal), positive control group (untreated group), 1 ml sweet basil aqueous extract,2 ml (SBAE),1 ml lemon balm aqueous extract,2 ml (LBAE) and (1+1) (SBAE) and (LABE). The best result in all groups was (1+1) (SBAE) and (LBAE) recorded the highest increase in (FI), (BWG) and (FER). Furthermore, this group recorded an increase in norepinephrine dopamine, serotonin, (HDL), (MDA), (SOD), (CAT) and (GSH). Whereas these groups recorded the lowest reduction in (AST), (ALT), (ALP), (TC), (TG), (LDL), (VLDL), urea nitrogen, creatinine and uric acid. Utilization: dried leaves of lemon balm and sweet basil possess many health benefits so use these herbs for 30 days to enhance many body functions.

DOI

10.21608/jhe.2024.376255

Keywords

brain toxicity, Oxidative Stress, aluminum chloride, Sweet basil, Lemon balm

Authors

First Name

Shaimaa

Last Name

Metwally Ali

MiddleName

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Affiliation

Nutrition and Food Science Department, Faculty of Home Economics, Helwan University

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Orcid

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First Name

Shaimaa

Last Name

H. Negm

MiddleName

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Affiliation

Home Economics Dept., Specific Education Faculty, Port Said University, Egypt

Email

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City

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Orcid

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First Name

Hany

Last Name

G. El-Masry

MiddleName

-

Affiliation

Nutrition and Food Science Department, Faculty of Home Economics, Helwan University

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Orcid

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Volume

40

Article Issue

3

Related Issue

49706

Issue Date

2024-09-01

Receive Date

2024-08-26

Publish Date

2024-09-01

Page Start

23

Page End

42

Print ISSN

1110-1210

Online ISSN

2356-9743

Link

https://jhe.journals.ekb.eg/article_376255.html

Detail API

https://jhe.journals.ekb.eg/service?article_code=376255

Order

376,255

Type

المقالة الأصلية

Type Code

1,062

Publication Type

Journal

Publication Title

مجلة الاقتصاد المنزلي

Publication Link

https://jhe.journals.ekb.eg/

MainTitle

The protective Effect of Ocimum basilicum and Melissa officinalis Aqueous Extract on Aluminum -Induced Brain Toxicity in Rats

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Article

Created At

25 Dec 2024