The goal of the current study is to evaluate the potential Effects of cake fortified with date seeds (CDS) against Aflatoxin B1-induced liver toxicity in rats. Thirty-five rats were separated into two main groups of seven each. The 1st main group was fed on basal diet and kept as negative control group, while the other rats were injected with Aflatoxin B1 at dosages of 2 mg/kg b.w. for 7 days, to induced liver toxicity. Then, rats reclassified into 4 equal subgroups as following: subgroup 1 served as the control positive group and 3 treated rat subgroups were fed basal diets plus cake supplemented with (5,10,15) % of Date Seeds, respectively. Hepatotoxic rats fed on an enriched diet with the three different levels of CDS had a significant decrease (P<0.05) in the activities of liver and kidney functions as well as in lipid profile, while serum high density lipoproteins, Albumin, Total Protein and the antioxidants enzymes glutathione peroxidase were significantly (P<0.05) improved while, significantly reduced Malondialdehyde compared to untreated hepatotoxic ats feed on the basal diet alone. In conclusion, it can be recommended that the necessity consumption of cake fortified with date seeds in the diets of liver diseases patients because of their antioxidants properties, and that play important role of health status.