The present work aimed to investigate the effect of matcha and yerba mate tea aqueous extract on the oxidative stress status of obese rats. Thirty-five adult male Sprague-Dawley rats were divided randomly into 7 equal groups (n=5) as follow: Group 1: negative control, was fed on a basal diet. Groups 2-7 were given lead acetate (LA) (200mg/L) in drinking water for 4 weeks to induce oxidative stress. The rats were then rendered obese by feeding on HFD for 4 weeks. Group 2 was kept as a positive control group (HFD + LA). Groups 3 and 4 were administrated orally with 0.5 and 1 ml of match aqueous extract, whereas 0.5 and 1ml of yerba mate aqueous extract were given to groups 5 and 6, respectively. Group 7 was oral administered with 1 ml of a matcha and yerba mate aqueous extract mixture for 4 weeks. At the end of experiment, rats were scarified and serum was collected for biochemical analyses. Results showed that the administration of HFD-LA group (control positive) resulted in significant elevations in body weight gain, feed efficiency ratio, peritoneal fat pad, serum total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-c), very low-density lipoprotein cholesterol (VLDL-c), leptin, nitric oxide (NO), malondialdehyde (MDA), alkaline phosphatase )ALP(, aspartate aminotransferase) AST(, alanine aminotransferase )ALT(, uric acid, urea and creatinine levels as compared to the negative control, and levels of serum high-density lipoprotein cholesterol (HDL-c( and glutathione peroxidase activity (GPx) were significantly decreased. On the other hand, oral administration with mate and matcha extract and their combination attenuated these adverse effects and biochemical alterations caused by HFD-LA administration. In conclusion, yerba mate and matcha exhibit antioxidants and hypolipidemic activity and are effective in reducing body weight in obese rats. The study recommends that consumption of yerba mate and matcha may be beneficial for individuals who suffer from obesity and hyperlipidemia.