The present study was conducted to find out the effectiveness the pulp, peels, seeds, and leaves of Jackfruit (Artocarpus Heterophyllus Lam.) on body weight changes and total visceral fat weight as well as histopathological changes of heart and aorta in obese rats with atherosclerosis. The experiment was conducted in two stages (each of 6 weeks), the objective of the first stage was the induction of obesity and atherosclerosis, while the second stage was to treat obese rats with atherosclerosis by feeding on the supplemented diet with 5 and 10% pulp, 5 and 7.5% (peels, seeds and leaves) of the jackfruits. The results revealed that the reduction in FBW, BWG VFW (g) and AI% were significantly ameliorated with increasing levels of the jackfruit pulp, peels, seeds and leaves. The optimum results at the rate of weight loss were in rats with obesity and atherosclerosis feed on the supplemented HFCD with jackfruit peels and leaves compared to that feed on the HFCD-supplemented diet with the pulp or seeds. With regard to the effect of jackfruit pulp, peels, seeds and leaves on the histopathological changes of heart and aorta, the present study revealed that photomicrograph of heart and aorta sections of obese rats with atherosclerosis fed on the supplemented HFCD with jackfruit pulp, peels, seeds or leaves at the different levels showing gradual improvement with increasing the levels, especially with jackfruit leaves, compared with the positive group. Generally, the ability of jackfruit pulp, peels, seeds and leaves to enhance the activity of anti-obesity and inhibit heart and aorta degeneration makes it a promising natural compound for the management of obesity and hyperlipidemia. However, more research is needed to fully understand the mechanisms of action and potential benefits of jackfruit pulp, peels, seeds and leaves in obesity and hyperlipidemia management.