Cardiovascular diseases are still the leading cause of morbidity and mortality worldwide caused by fatal angina. The underlying pathological mechanism of atherosclerosis is a narrowing of the arteries caused by a buildup of plaque, leading to insufficient blood flow to vital organs, mainly the heart and the brain. The present study was conducted to find out the effectiveness the pulp, peels, seeds, and leaves of Jackfruit (Artocarpus Heterophyllus Lam.) on body weight changes and total visceral fat weight as well as some of biochemical parameters in obese rats with atherosclerosis. The experiment was conducted in two stages, each of 6 weeks. The objective of the first stage was to induce obesity and atherosclerosis in rats, while the second stage was to treat obese rats with atherosclerosis by feeding on the supplemented diet with 5 and 10% pulp, 5 and 7.5% peels, 5 and 7.5 % seeds and 5 and 7.5 % leaves of the jackfruits. The results, revealed that, the reduction in FBW, BWG VFW (g) and AI% as well lipid profile and increased activities of antioxidant enzymes (CAT, GPx and SOD) were significantly ameliorated with increasing levels of the jackfruit pulp, peels, seeds and leaves. The optimum results regarding to weight loss were in rats with obesity and atherosclerosis fed on the supplemented-HFCD with jackfruit peels and leaves compared to that fed on the HFCD with pulp or seeds. Generally, the ability of jackfruit pulp, peels, seeds and leaves to enhance the activity of anti-obesity and inhibit Atherogenic index as well the improvement of liver function and activities of antioxidant enzymes makes it a promising natural compound for the management of obesity and hyperlipidemia. However, more research is needed to fully understand the mechanisms of action and potential benefits of jackfruit pulp, peels, seeds and leaves in obesity and hyperlipidemia management.