The purpose of the current study was to assess the impact of various probiotic dietary additives on the blood components and immunological parameters of Hi-Plus developing rabbits in the specific environmental conditions of North Sinai. A group of 48 Hi-Plus rabbits, 5 weeks age and 811.00 ± 20 g average body weight, were allocated into four experimental groups. Each group was randomly allocated into three equal replicates, with four rabbits each. The first treatment group was administered the basal diet (control). In the second, third, and fourth groups, were administered the basal diet supplemented with 10 ml ZAD^® per kilogram of diet, 10 g ZADO^® per kilogram of diet, and 10 g YEAST (saccharomyces cerevisiae) per kilogram of diet, respectively. The experiment lasted to 7 weeks. The findings of this study indicate that the rabbits who were administered probiotic treatments exhibited a significant increase (P<0.05) in plasma total protein and globulin concentrations when compared to the control group. The rabbits that were treated with ZADO^® and YEAST exhibited a significant drop (P<0.05) in plasma triglyceride levels when compared to the control group. Total antioxidant capacity were increased (p<0.05) for different probiotic treatments when compared to the control group. The concentration of ALT level was found to be significantly lower (P<0.05) in the rabbits who were fed YEAST as compared to the control group. The rabbits who were fed YEAST exhibited a statistically significant rise (P<0.05) in plasma levels of IgG and IgA when compared to the control group. In conclusion, the addition of probiotics ZADO^® and YEAST at a concentration of 1% to the diets of Hi-Plus rabbits during the growing phase may have beneficial effects on blood components and immunological condition.