This study was conducted to evaluate the effect of supplementing Baladi goat's ration with different levels of Saccharomyces cerevisiae (ACTISAC) on feed intake, rumen fermentation, blood parameters, digestibility, and growth performance under conditions of Aswan, Egypt. Sixteen Baladi goats, aged between 10 and 12 months and with an average body weight of 18.28 ± 0.8 kg, were divided into four groups, with four goats in each group. The experimental groups were fed a basal ration containing 50 % concentrate feed mixture and 50 % alfalfa hay plus 0, 2.5, 5.5, and 7.5 g yeast culture for groups T1, T2, T3, and T4, respectively, for an experimental period of 155 days. Results showed that goats in treated groups increased (P < 0.05) ruminal pH and ruminal temperature while ammonia-N and total volatile fatty acids (TVFAs) were not affected (p > 0.05) by ACTISAC. The levels of blood serum albumin, triglycerides, glucose, ALT, AST urea, creatinine, and uric acid were not affected (P>0.05) by the addition of yeast, while total protein, globulin, and cholesterol were increased (P<0.05) for goats fed ACTISAC. Moreover, dry matter intake was increased (P<0.05) compared to control group (T1), and the highest values were recorded for lambs fed 5.5 g ACTISAC (506.94 g/d). The supplementation of ACTISAC did not result in any significant effect on nutrient digestibility's. Goats' growth performance was affected by ACTISAC supplementation; total gain (TG) and average daily gain (ADG) values were higher (P<0.05) in the treated groups than in the control. In conclusion, ACTISAC supplementation improved growing goats' feed intake and blood parameters and enhanced their growth performance