Abstract Background: Recently, health care settings have granted increased attention to nurses' emotional labor due to its effect on the quality of their performance. Job embeddedness is well proved to greatly influence nurses' performance and fosters positive and green workplace practices, so it is expected to enhance nurses' emotional labor. Aim : To assess the mediating role of job embeddedness on relation between the psychosocial safety climate and emotional labor of staff nurses. Subjects and Method: Design: An exploratory descriptive. Setting: Inpatient medical, surgical, and intensive care units at Benha University Hospital., Egypt. Subjects: A simple random sample of staff nurses who met inclusion criteria, their final size was 370 out from 1220 staff nurses. Data collection: Three tools were utilized. Job embeddedness questionnaire, psychosocial safety climate questionnaire, and Emotional labor scale. Results: There were moderate levels of job embeddedness and psychosocial safety climate as perceived by over half of the nursing staff studied. Also, staff nurses had a moderate level of emotional labor as reported by more than half of them. Conclusion: There were highly significant positive correlations among overall scores of emotional labor, job embeddedness and psychosocial safety climate. Moreover, job embeddedness had indirect significant role partially mediated the relation between psychosocial safety climate and emotional labor. Recommendations: Nursing managers should develop a series of activities to improve nurses' job embeddedness, and also develop organizational strategies that maintain good psychosocial safety working climate.