Background: Mechanical ventilation is a form of life support for 90% of critically ill patients. 
Aim: To evaluate the effect of cough augmentation techniques on the airway clearance of a 
mechanically ventilated patient. Subjects and Method: Design: Quasi- experimental study. 
Setting: This study was conducted at Anesthesia Intensive Care Unit of Tanta Emergency 
Hospital. Subjects: 60 cases divided into two groups 30 in each in the above previously 
mentioned setting. Tools: two tools were utilized in this research. Tool I: Mechanically 
Ventilated Patients Evaluation Sheet, Tool II: Patients' Hemodynamic Parameters Sheet.
Results: patients with a specific medical condition have a significant increase in respiratory rate, 
heart rate, systolic and diastolic blood pressure, and oxygen saturation after 25 minutes of 
intervention (p<0.05). The study and control groups didn‘t show significant differences in 
temperature (p<0.05). Mean pulmonary filtration rate (PH) didn‘t change significantly, but a 
significant decrease was observed in the third day only among the study group. Conclusion: The 
study found that cough augmentation techniques significantly improved airway clearance in 
mechanically ventilated patients, leading to increased hemodynamic stability, oxygen saturation, 
blood gas exchange, and breathing stability. Recommendation: The investigation suggests 
further multi-center studies and the use of cough augmentation techniques in managing 
secretions complaints in Intensive Care Units.