Background: Evidence-based nursing management is the systematic manner of the best available evidence to management decision-making, with the goal of enhancing the performance of healthcare organizations. Aim: This study aimed to assess the nurse managers' perspective towards evidence-based nursing management. Method: Setting: This study was conducted at four hospitals; including the International Teaching Tanta Hospital, and Kafr El-Shiekh University Hospital, which are affiliated to Ministry of Higher Education and Scientific Research, as well as Al-Minshawi General Hospital and Kafr El-Shiekh General Hospital, which are affiliated to Ministry of Health and Population. Subjects: This study involved all nurse managers (n=159) in four hospitals. Tools: Two tools were used: nurse managers' evidence-based nursing management knowledge questionnaire and nurse managers' opinions about evidence-based nursing management questionnaire. Results: 60.4% of nurse managers had a moderate level of knowledge about evidence-based nursing management. 74.8% of nurse managers had moderate utilize of evidence's sources. The majority of nurse managers identified that the teamwork factor was the most common frequent barrier and facilitator at the same time. Conclusions: The nurse manager had moderate knowledge about evidence-based nursing management. There was the significance positive correlation between levels of nurse managers' knowledge of evidence based-nursing management and their levels of nurse manager utilization of evidence sources in Ministry of Health and Population hospitals. Recommendations: Developing programs to enhance knowledge of evidence based-nursing management and utilization of evidence sources in decision-making process