Background: Globally, work-related stress had a significant impact on health-care providers. 
According to WHO, nurses are the largest health care group in the world; nurses and 
midwives represent about 50% of the global health workforce Aim: To assess determinant of 
work-related stress among nursing staff. Method: This paper analyses 23 papers relating to 
work related stress among hospital nurses derived from original searches available on credible 
databases; PubMed, CHINAL, MEDLINE, EMBASE, PsycINFO, MedRxiv and Google 
Scholar.  Covering English languish from 2018 till 2023, published in international journals. 
Design: Systematic review. Sample: The studied populations were nurses or health care 
professionals who had worked at public and private hospitals. Results: The overall magnitude 
of work-related stress among nurses working in hospital was almost half. The average of 
work-related stress among nurses working in public hospitals is relatively high compared with 
nurses in private hospitals. Additionally, the workload and manpower availability are most 
significant stressors among the nurses. The management of the hospitals needs to look into 
these two issues to help overcome the stress faced by the nurses. Determinates of work
related stress were Sex, operating and intensive care units, working experience, and type of 
institution (public and private hospitals). Recommendations: Hospital's management need to 
consider the nurses workload to help overcome the stress faced by the nurses. There is a 
crucial need for reducing workload and providing stress management training to reduce 
nurses' work-related stress.