Background: Breast cancer is the most often diagnosed disease and the main cause of 
death between females globally. Different chemotherapeutic are used, such as 
doxorubicin or epirubicin in combination with cyclophosphamide, and paclitaxel 
(Taxol) or docetaxel in combination with carboplatin Aims: the study aimed to 
evaluate effect of implementing bundle of care on breast cancer patients paclitaxel 
induced peripheral neuropathy and quality of life. Methods: Research Design: A 
quasi-experimental research design was used to conduct the study. Subjects: A 
purposive sample of 60 adult subjects newly diagnosed with breast cancer and treated 
with paclitaxel. Setting: This study was conduct at oncology treatment center and 
nuclear medicine department at Qena university hospital. Data collection Tools: Four 
tools were used for data collection: Tool I: Breast cancer patient's structured 
interview questionnaire. Tool II: The Chemotherapy Induced Peripheral Neuropathy 
Assessment (CIPNA). Tool III: Functional Breast (FACT-Tool IV. Neuropathy 
Grading Assessment Scale. Results: The mean Assessment of Cancer Therapy 
scores of PIPN -QOL for the study group increased one and two months after bundle 
of care implementation compared to upon admission in the study with highly 
statistically significant differences between them at p < 0.001. Statistically significant 
differences regarding sensory and motor neuropathy grading (G1, G2, G3, and G4) 
was found after one and after two months of implementing bundle of care instructions 
between both group p≤ 0.05. Conclusion: Implementing bundle of care has a positive 
effect on PIPN-QOL. The study group demonstrates a statistically significant 
Vol. 33.  No.2 May, 2024                                                                             
287 
Tanta Scientific Nursing Journal                          
(Print ISSN 2314 – 5595 ) ( Online ISSN 2735 – 5519) 
improvement regarding sensory/motor neuropathy grading and quality of life. 
Recommendations: The bundle of care instructions should serve as the basis for 
routine nursing care for patients receiving paclitaxel to improve their peripheral 
neuropathy and quality of life.