Background: Esophagogastroduodenoscopy is gold standard procedure for detecting upper 
gastrointestinal disorders.Aim:this study was conducted to evaluate the effect of nursing 
instructions 
on clinical outcomes for patients undergoing upper gastrointestinal 
endoscopy.Design:Quasi experimental research design was utilized.Setting : the study 
conducted at New Surgeries Hospital affiliated of Tanta University Hospitals.Subject: It 
consisted of purposive sample of 60 Upper endoscopy patients who  selected and  divided  into 
two equal groups.Tools:Three tools  used in this study for data collection:Tool I:Patients' 
Assessment Structured Interview.Tool II:Patient's Knowledge Assessment Questionnaire 
regarding Upper Gastrointestinal Endoscopy.ToolIII:Patients'Clinical Outcomes Assessment 
Tool composed from three parts: Part A: Tolerance Assessment Sheet;Part B: State Trait Anxiety 
Inventory.The Part C:Post endoscopy Patients' Observation for risks of Complication 
Checklist.Results:there were statistical significant  improvement in total knowledge level  study 
group had high level of knowledge(76.7) while control group had (16.7%).state anxiety score 
immediately post giving nursing instructions, about more than half(63.3.0%)of control group had 
sever level of anxiety compared to the minority of study group (10.0%).after giving nursing 
instructions to study group.Conclusion: Implementation of nursing instructions had a positive 
impact on clinical outcomes. Recommendations: Educational Program should be implemented 
as a routine nursing care for patients undergoing upper endoscopy procedure.