Background: Non-invasive ventilation is an effective way for providing respiratory support for
neonates with respiratory insufficiency. It has significantly decreased the need for endotracheal
intubation. However, non-invasive ventilation has been associated with pressure injures. Aim: to
assess nurses' performance regarding non-invasive ventilation of neonates and its relation to
associated pressure injuries. Design: descriptive correlational research design. Settings: this study
was conducted at Neonatal Intensive Care Units of El-Menshawy General Hospital, Kafrelsheikh
General Hospital and Kafrelsheikh University Hospital. Subjects: All pediatric nurses (110) who
are working at the previously mentioned settings and all neonates (110) received non-invasive
ventilation at the time of data collection were involved in the study. Tools of data collection: three
tools were used, Tool (I) non-invasive ventilation and pressure injuries questionnaire, Tool (II)
nurses' assessment of hyperemia and Tool (III) nurses' practice observational checklists. Results:
the current study revealed that less than three- quarters of the nurses had low level of knowledge
and none of them had high level of knowledge. Nurses' practice regarding non-invasive ventilation
and skin care was unsatisfactory. There was a highly statistically positive correlation between
nurses' total knowledge and nurses' total practice related to non-invasive ventilation and skin care.
Conclusion: the studied nurses had poor level of knowledge and unsatisfactory practice regarding
non-invasive ventilation and skin care. Recommendations: educational program and periodic
workshops regarding non-invasive ventilation and neonatal skin care should be provided for nurses
working at NICU