Background: The spleen, a multifunctional organ, plays a pivotal role in active
hematopoiesis and immune monitoring. Splenomegaly, characterized by an increase in spleen
size due to cellular or tissue components or vascular engorgement, necessitates careful
evaluation. Aim of the study: evaluate the effect of educational program on mothers'
knowledge and practices regarding their children with splenomegaly. Research Design: A
quasi-experimental research design was used. sample: Aconvenient sample of sixty mothers
and their children with splenomegaly from Pediatric Medical Department and Hematology
Department of Tanta University Hospital. Two tools were utilized: Tool I: Mothers'
knowledge regarding splenomegaly questionnaire. Tool II: questionnaire to collect Mothers'
reported practice regarding care provided to their children with splenomegaly. results: more
than three quarters of mothers had a low level of knowledge about splenomegaly preprogram
implementation while immediately and after one month from the program implementation the
total scores of mothers, knowledge were improved. Also, the majority of studied mothers had
un satisfactory level of reported practice preprogram implementation while immediately and
after one month from the program implementation there was a marked improvement in the
total scores of mothers' practices. Conclusion: There was a significant effect of the
educational program on improving the mothers' knowledge and practices regarding their
Children with splenomegaly. Recommendations: educational programs should be organized
for mothers to elevate their awareness and competence in providing care for children with
splenomegaly