Background: Total parenteral nutrition is vital for children who unable to consume their
food through gastrointestinal system, there are a lot of complications; the most common and
serious is blood infection. The study was aimed to evaluate the effect of educational
program on nurses' performance about prevention of infection among children receiving total
parenteral nutrition. Subjects and method: Subjects: A convenience sampling of thirty five
nurses from Tanta University Hospital and fifteen nurses from Al-Mabra Hospital. Fifty
children at Intensive Care Units that were received total parenteral nutrition. Setting: The
study conducted at Pediatric Intensive Care Unit of Tanta Main University Hospital and Al
Mabra Tanta Hospital. Four tools were used to collect data: Tool I; structured interview
schedule to collect sociodemographic data of nurses and assess nurses, knowledge, Tool II;
assess nurses performance using observational check lists, Tool III; laboratory investigation
related to infection of children receiving total parenteral nutrition: (ESR, CRP, WBCS, Blood
culture), Tool IV; physiological and physical measurement of children Results: revealed
that educational program have positive effect on both knowledge and practice of nurses
regarding prevention of infection and significance improvement in condition of children
receiving total parenteral nutrition. Conclusion: Educational program have positive effect on
performance of nurses, physiological and physical condition of children and prevention of
infection occur with total parenteral nutrition. Recommendation: implementation of
educational and training programs should be encouraged and repeated for pediatric intensive
care unit children who received total parenteral nutrition to prevent infection.