Continuous Positive Airway Pressure refers to the application of positive pressure to the airway of 
a spontaneously breathing neonate throughout the respiratory cycle. It is a respiratory support 
method for neonates with either upper airway obstruction or respiratory failure. The present study 
was aimed to evaluate the effect of educational guidelines program on nurses performance for 
Caring of neonates receiving Continues Positive Airway Pressure ventilation . Research design: A 
quasi- experimental research design was used in the present study. The study was conducted at 
Neonatal Intensive Care Unit of Tanta University Hospital .Subjects: Convenience sampling of 60 
nurses who working at the above previously mentioned setting . Two tools were used to collect 
data: Structured interview schedule for nurses' knowledge regarding Continues Positive Airway 
Pressure and Observational checklist for nurses caring of neonates receiving Continues Positive 
Airway Pressure. Results : Represented that more than half of nurses had poor knowledge and the 
majority had unsatisfactory reported practices before educational guide line program 
implementation . Conclusion : There was a significant improvement of total level of nurses‟ 
knowledge and practice regarding nursing care of neonate receiving Continues Positive Airway 
Pressure immediately and after one month from educational guidelines program implementation .
Recommendations: In -service training program should be conducted periodically and regularly 
for teaching nurses working at Neonatal Intensive Care Unit for caring of neonate receiving 
continuous positive airway pressure and manual log book about care of neonates and Continues 
Positive Airway Pressure Ventilation should be available for nurses at Neonatal Intensive Care 
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