Background: Nurses have different reactions to change initiative, because they have 
different personal experiences, motivation level so, creating motivational environment in 
health care organization among the nurses is considered most important role of hospital 
change agent. Aim of the study: Assess nurses' perception toward organizational change 
and its relation to work motivation. Design: Descriptive correlational research design was 
used in this study. Setting: It was conducted at El- Menshawy General Hospital affiliation 
of Ministry of Health and population. Subject: Stratified random sampling of 
nurses(n=260). Tool: Structured questionnaire consisted of three parts part I: Subject 
characteristics. Part II: Nurses` Perception toward Organizational Change part III: 
Nurses` Work Motivation. Results: More than half of nurses had a low level of perception 
toward organizational change, and work motivation. Conclusion: There was a statistically 
significant positive correlation between levels of nurses` perception regarding 
organizational change and their work motivation. Recommendations: Hospital 
management describes tasks and timelines during change process to nurses and provides 
them with time and resources required to implement change.