Background: Virtual reality technology is a remarkably effective method to distract 
attention from painful stimuli. It is a promising and attractive intervention to help reduce 
anxiety and pain of children undergoing painful procedures. Aim: to evaluate the effect 
of applying virtual reality glasses on reducing pain and anxiety of children undergoing 
chemotherapy. Method: A quasi-experimental research design was used to conduct the 
study at the Oncology Department of the Specialized Children's Hospital in Benha, 
affiliated with the Ministry of Health and Population, Egypt. A purposive sample of 50 
children undergoing chemotherapy was included. Four tools were used for data 
collection: A structured interviewing questionnaire, pain rating scale, Beck anxiety 
inventory scale, and Physiological assessment of children. Results: The results of the 
study revealed that more than half (52.0%) of the children experienced severe pain before 
the intervention, while less than two-thirds (60.0%) of the children reported no pain after 
the intervention. Furthermore, less than two-thirds (60.0%) of the studied children had a 
high anxiety level before the virtual reality glasses intervention. However, during the 
intervention, less than half (46.0%) of the studied children had a low anxiety level 
Conclusion: Children who received the virtual reality glasses exhibited less pain and 
anxiety score compared to children who did not receive them Recommendations: Virtual 
reality should be used as a technology to reduce pain and anxiety during painful 
procedures of children admitted in pediatric oncology departments.