Systemic lupus erythematosus in children is a multisystem disease with extensive organ 
involvement. Mothers may struggle to manage their child‟s health, their own emotions and had 
positive effect on mothers quality of life and self-efficacy. The aim of the study: Was to 
evaluate effect of implementing family empowerment model on quality of life and self- efficacy 
of mothers of children with systematic lupus. Research design: A quasi-experiental design.
Setting: This study was conducted at Rheumatology and Immunology Department and 
Outpatient Clinics at Benha University Hospital Tools of data collection: Tool (I): Mothers 
knowledge questionnaire; A structured interviewing questionnaire Sheet (pre/post): It was 
divided into four main parts: part (1): Personal characteristic of the studied mothers, Part (2): 
Characteristics of the studied children, Part (3): Medical data of studied children and Part (4): 
Mothers knowledge Assessment questionnaire Tool (II): Mothers Quality of Life 
questionnaire. Tool (III): mothers Self-efficacy Scales .Tool (IV): Mothers Reported 
Practices Assessment Sheet, Results there was a highly statistically significant differences 
between total scores of knowledge and reported practices levels after family empowerment 
implementation. Also, that there was a highly statistically significant differences between 
mother‟s self-efficacy and quality of life. Conclusion: implementation of family empowerment 
model were improving quality of life and self- efficacy of mothers of children with systematic 
lupus Recommendation: Family empowerment program should be conducted for caregiver 
periodically and regularly to enhance care of their children with Systematic lupus erythematous.