Background: Adequate dietary oral intake is important to maintain nutritional status for 
patients after pancreaticoduodenectomy. Aim: This study was conducted to evaluate the effect 
of nursing instructions and oral postoperative nutritional supplementation on outcomes of 
patients following pancreaticoduodenectomy. Patients and methods: Research design: Quasi 
experimental (non-randomized) design. Sample and setting: Thirty-four adult patients 
diagnosed with pancreatic cancer and underwent pancreaticoduodenectomy. Patients were 
assigned non-randomly into 2 groups. Admitted patients during the first six months in 
hepatobiliary surgical unit at Al-Rajhi Liver and Gastroenterology Assiut University Hospital 
were included as control group (16 patients), while patients admitted during the next six 
months were included as study group (18 patients). Tools: Patient assessment sheet, short-form 
mini nutritional assessment scale, and Clavien-Dindo classification of surgical complications.
Results: Study finding revealed a statistical significant difference (p = 0.0001) with 
improvement in study group after 3 months postoperatively regarding nutritional status and 
albumin and protein levels. Reduced length of hospital stay for study group 10 (55.6%) less 
than 10 days compared to control group 10 (62.5%) from 10-15 days. Complications did not 
occur in about one-third of study group 6 (33.3%) compared to 3 (18.8%) in control group. 
Conclusion: Nursing instructions and oral postoperative nutritional supplementation reduced 
hospital stay, improved nutritional status, albumin and protein levels and reduced postoperative 
complications. Recommendation: Nursing instructions (educational booklet) and oral 
postoperative nutritional supplementation should be utilized in all liver and gastroenterology 
hospitals as teaching guide for patients undergoing pancreaticoduodenectomy