Respiratory problems have a significant impact on morbidity and mortality in children with cerebral palsy. Aim: Evaluate the effect of implementing educational intervention on mothers' knowledge and practices regarding respiratory problems for children with cerebral palsy. Method: A quasi-experimental research design was used for a convenience sampling of 60 mothers and their cerebral palsy children at outpatient clinic and Pediatric Inpatient Neurology Unit of Tanta Main University Hospital. Tools: Two tools were used to collect the required data: structured interview schedule and observational checklists to assess mothers` practices regarding the management of respiratory problems. Results: Most of mothers had low level of knowledge and three quarter of them had unsatisfactory practice pre educational intervention, whereas immediately and month later, improved mothers' scores on knowledge and practice. Conclusion: There was a significant improvement in mothers` performance about care of respiratory problems for cerebral palsy children. Recommendation: Provides frequent regular education intervention programs should be provided in all health facilities to mothers