The effectiveness of treating wheat grains treated with petrole‌um—ether or chloroform of lupin seed extracts against S. aryzao and n dorninica was determined and Lc25,1_050 and Loa s's levels were estimat‌ed Results showed that S. oryzae adults were more sensitive to both extracts than R. domirrica. Treatments with both tested extracts caused severe reduction in number of eggs deposited and in the percentage of progeny, especially at Legs's level. At this level no offspring was pro‌duced by the adults and complete protection at wheat grains was ob‌tained against S. oryzae and R. dominica up to 90 days . Lupin extracts had a detrimental effects on germination of wheat grains especially at the high concentrations. Tested extracts had a dilferent effects on both cholinestrase and peroxidase enzymes level in S. oryzae and R. dominica.