In a goat milking farm (Saanen bread) at Ei Nobaria area at Alexandria Governorate, 50 out of 250 goats showed clinical manifestations refered to caprine viral papillomatosis. The warts were confined to the udder and teats of affecting does. Twenty-five proper samples from warts were taken for virological and pathological studies. The virus isclation and propagation was done on human epidermoid carcinoma (HEP-2) derived from larynx carcinoma. Etectron microscopy on wart tissues revealed the characteristic shape of an associated appearing virus in the form of dente electron granules in the nuteus of the upper part of epiderms. The epidermis revealed parakeratosis, hyperkeratosis as well as acanthosis. Three out of 25 samples showed squamous cell carcinoma characterized by the presence of bird nests of different shapes and sizes. Diseased goats were vaccinated with prepared autogenous vaccine from the tissues cf warts. One month after vaccination the warts showed regression and complete releaf of all diseased cases. The clinical, electron microscopy and histopathological findings were illustrated in 12 figures.