One hundred and fifty diseased and freshly dead rabbits were examind for mycotic and bacterial organisms. The examined rabbits showed diarrhoea and/or enteritis. The most recovered mycotic organisms were Aspergillus fumigatus, Aspergillus flavus, Aspergillus tiger, Mucor racemosus and Candida albicans. The recoved bacteria were Escherichia coli, Kiebsielfa pneumoniae, Pseudomonas aeruginosa and Proteus vulgaris. Serotyping of Escherichia colt isolates revealed 4 different servovars; ❑119, 0128, 0157 and 0178. Salmonella was not isolated from rabbits. Groups of 5 NewZealand White weaned rabbits of 30 days old were used to test the pathogenicity of isolated Aspergillus furnigatus, Mucor racemosus, Geotrichium candidum, Candida albicans and different serovars of Escherichia coll. Mixed infection of Aspergillus fumigatus, Candida albicans and Escherichia coli was also studied. Clinical and pathological changes were recorded. The main pathological changes were congestion, haemorrhages and necrosis in most examined organs, in addition to presence of periodic acid schiff (PAS) positive fungal spores in hepatic and intestinal tissues.