The main purpose of the present study is to assess the pesti‌cides and heavy metals contamination in Ismailia governorate that might contribute a risk to human health or environment. The long-term objec‌tives of EFARP* have been defined as strengthening applied agriculture research in Ismailia governorate. This will result in creating productive, sustainable and successful farming systems. This study has contributed to increasing knowledge about the presence of toxic hazardous com‌pounds in the environment of Ismailia governorate as an example of new lands. Monitoring of organophosphorus, carbamate and synthetic py‌rethroids pesticides, which are commonly used in Egypt for pest control, was carried out in addition to persistent organochlorines, which were prohibited several years ago. Heavy metals; lead, cadmium and copper were also included in the monitoring program. One hundred and ten sam‌ples (40) plants, (40) soil and (30) water, samples were examined for 63 pesticides. Banana, clover, carrot, dry beans, cowpea, maize, cucum‌ber, strawberry, tomato, potato, mandarin, orange and dill plant samples were collected from Ismailia, Qantara West, Qantara East, Fayed and Kassasin (Ismailia governorate). Irrigation, drainage and drinking water samples were collected from Ismailia governorate. No violations were ob‌served in all analyzed plant samples, while low residues were detected in soil and waater samples. The data demonstrates the contamination of tomato, potato, and dill samples with profenofos, dimethoate and malathion pesticide residues. Dicofol, chlorothalonil and deltarnethrin residues were detected in strawberry, tomato and maize samples. The HCH isomer was detected in potato samples collected from Qantara west, while 'p, p'-DDE residues were detected in potato samples collected from Fayed. Dimethoate was the only organophosphrous pesticide residues, while pirimicarb was the only carbamate pesticide residue found in soil samples. However, dicofol, permethrin, triadimefon, tetradifon and DDT complex from the organochlorine and pyrethroid groups were detected in soil samples collected from Ismailia governorate. Fifty samples of water, soil and plants were examined for copper, lead and cadmium. Copper residues were detected in low concentration. However, lead and cadmium residues varied from being undetectable to very low concentrations.