Addition of sulfur or gypsum amendments and their effect on ni­trogen, phosphours and potassium availability in saline-sodic soil as well as their contents in wheat grain were studied in Koam-Oshem area, El­Fayoum Governorate. The obtained results revealed that the availability of N, P and K in soil and their content in wheat grain increased by in­creasing the application rates of the studied amendments. However, in­creasing the application rates more than 1.5 kg sulfur/plot or 7.5kg gypsum/plot decreased the relative increment of nutrient availability and content in both soil and grains. Relative wheat grain yield increased by 151% and 119% kg compared to control treatment at the application rates of 2.0 kg sulfur / plot and 10 kg gypsum/plot respectively. These results might be due to the effect of soil amendments on some factors affecting the nutrient availability in the soil.