Nowadays, the direction of the scientist is to produce combined vaccines as being economic. In this study, there was a trial to produce a combined Rift Valley Fever, Pasteurella multocida and Pasteurella haemo­lytica oil adjuvant vaccine and inactivated with binary ethyleneimine (BEI). Also, the immune response of cattle was studied. We used twelve susceptible 6 month old calves classified into four groups. Each group contained three calves. The first group was vaccinated with monovalent Rift Valley Fever vaccine, second group was vaccinated with conlined Rift Valley Fever and pasteurella vaccine, the third group was vaccinated with Pasteurella haemolytica and Pasteurella multocida vaccine alone, and the forth group was left as a control non-vaccinated. The first three groups received a booster dose after one month. The animals were ob­served and their immune response were investigated for 6 months. The results revealed that, concerning the immune response to pasteurellae antigens, there was no competition with Rift Valley Fever antigen as non-significant differences were noted between the serological and im­munological test results of the single and combined vaccines. All vacci­nated animals acquired a protective level of antibodies against RVF virus or pasteurella strain. It can be concluded that the combined RVF and pasteurella oil adjuvant vaccine can be used effectively in controlling both diseases in cattle.