In Egypt, wheat stem rust survey gave evidence to the presence of ten races (11. 14, 15, 17, 19. 24, 34, 39, 53 and 122) in 1996, five races (10, 11, 14. 15, and 39) in 1997 and eight races (4, 10, 11. 24, 34, 39, 98 and 207) in 1998 growing seasons. Over the three years of study, races 11 and 39 were the most common representing and 31.86 % frequency, respectinly. Over the three ;ears of study, frequency of virulence among the fifty-six identified isolates on ninteen monogenic lines was determined. The most effective gene was Gt+ exhibiting 67.88% efficacy. On the other hand, the other genes showed susceptibility for the tested iso‌lates. The Pathogenicity Association Coefficient (PAC) and Virulence Association Coefficient (VAC) were determined. Most of the gene pairs were effective with low PAC and VAC or nearty equal values of PAC and VAC.